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Description
Amikacin works by binding to the bacterial 30S ribosomal subunit, inducing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. It interferes with the translocation of tRNA from the A-site to the P-site. Amikacin must be given by the intravenous or intramuscular route; it is not absorbed orally.
Specifications
Specifications
| Physical Form | Powder |
| CAS | 37517-28-5 |
| pH | 9.5 to 11.5 (1% aq. soln.) |
| Potency | ca. 900μg/mg |
| Quantity | 250 mg |
| Optical Rotation | 100.5° |
| Molecular Formula | C22H43N5O13 |
| Boiling Point | 981.8°C (760mmHg) |
| Synonym | 1-N-[L(-)-4-Amino-2-hydroxy-butyryl] kanamycin A, O-3-Amino-3-deoxy-a -D-glucopyranosyl-(1 ---> 6)-O-6-amino-6-deoxy-a-D-glucopyranosyl-(1 ---> 4)]- N1 -(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine, Lukadin |
| Solubility Information | Sparingly soluble in water. |
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