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Ampicillin sodium salt

Product Code. 15465979
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Product Code. 15465979 Supplier Thermo Scientific Alfa Aesar Supplier No. J63807.06
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Description

Ampicillin sodium salt, CAS # 69-52-3, is the sodium salt form of ampicillin, a semisynthetic derivative of aminopenicillin compound that shows antibacterial activity against both gram-positive and gram-negative bacteria. | CAS: 69-52-3 | C16H21N3NaO4S | 374.411 g/mol

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Ampicillin sodium salt is a semi-synthetic derivative of penicillin with a broad-spectrum antibacterial activity against several species, including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Ralstonia solanacearum

• It can inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, inhibiting peptidoglycan synthesis, which is an essential component of the bacterial cell wall

Application

• Ampicillin sodium salt has been used as a reagent for transformed cells that express β-lactamase

• It can be used to select for ampicillin resistance in mutated and transformed cells

• Ampicillin sodium salt acts as a structural analog of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme preventing the cross-linking of the cell wall peptidoglycan, which is necessary for the growth of the bacterium

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 69-52-3
Molecular Formula C16H21N3NaO4S
Molecular Weight (g/mol) 374.411
MDL Number MFCD00064313
InChI Key BSFVNXCYXDYHOD-ZQDFAFASSA-N
PubChem CID 131673879
IUPAC Name (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;molecular hydrogen;sodium
SMILES [HH].CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C.[Na]

Specifications

Type Ampicillin Sodium Salt
Physical Form Powder
Melting Point 215°C
Color White
Quantity 5 g
Beilstein 4119211
Merck Index 14,586
Solubility Information Freely soluble in water; Sparingly soluble in acetone
Formula Weight 371.39
Chemical Name or Material Ampicillin sodium salt

Safety and Handling

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Product Identifier
  • Ampicillin sodium salt
 Signal Word
  • Danger
 Hazard Category
  • Respiratory sensitiser Category 1
  • Skin sensitiser Category 1
 Hazard Statement
  • H317-May cause an allergic skin reaction.
  • H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P284-[In case of inadequate ventilation] wear respiratory protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
  • P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .
 Supplemental information
  • MIXTURE LIST-Contain: Ampicillin sodium salt
SDS

RUO – Research Use Only

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