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Invitrogen™ AMPK beta-2 Monoclonal Antibody (376938)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561346
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
AMPK Beta 2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Specifications
| AMPK beta-2 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| O43741, Q6PAM0 | |
| Prkab2 | |
| E. coli-derived recombinant human AMPKB2, Met1-Ile272. | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 376938 | |
| Unconjugated | |
| Prkab2 | |
| 5730553K21Rik; 5'-AMP-activated protein kinase subunit beta-2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-catalytic subunit; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; AMPKbeta2; AW049591; BB124140; Prkab2; protein kinase AMP-activated non-catalytic subunit beta 2; protein kinase, AMP-activated, beta 2 non-catalytic subunit | |
| Rat | |
| Protein A/G | |
| RUO | |
| 108097, 5565 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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