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Invitrogen™ Angiopoietin 2 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148457
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Description
Reconstitute at 1 mg/mL in sterile PBS.
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
Specifications
| Angiopoietin 2 | |
| Polyclonal | |
| Unconjugated | |
| ANGPT2 | |
| AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand | |
| Goat | |
| Protein A/G | |
| RUO | |
| 285 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 1 mg/mL | |
| PBS with trehalose and no preservative | |
| O15123 | |
| ANGPT2 | |
| Mouse myeloma cell line NS0-derived recombinant human Angiopoietin-2, Asp68-Phe496 and Tyr19-Phe496. | |
| 1 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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