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CD220 Mouse, Unlabeled, Clone: 46, BD
Mouse Monoclonal Antibody
168.20 €
Specifications
| Antigen | CD220 |
|---|---|
| Clone | 46 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
Description
Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit. The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines. Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.
Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human Insulin pro-receptor β subunit 1006-1144
Formula Weight [Chemical]: 95kDa
Immunofluorescence, Immunoprecipitation, Western Blotting
Specifications
| CD220 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Immunology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified | |
| Insulin Receptor β |
| 46 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Mouse, Rat | |
| Human Insulin pro-receptor β subunit 1006-1144 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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