missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CTCF Mouse, Unlabeled, Clone: 48, BD
Mouse Monoclonal Antibody
253.48 € - 476.00 €
Specifications
| Antigen | CTCF |
|---|---|
| Clone | 48 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15886109
|
BD Biosciences
612148 |
50 μg |
 265.00 € 253.48 € / 1 set Save 11.52 € 4% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15896109
|
BD Biosciences
612149 |
150 μg |
476.00 €
1 set |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
The family of nucleic acid-binding C2H2 type zinc finger transcription factors is divided into two classes. One class consists of small proteins (Gli1, Krox-20, WT1, Egr-1, and Sp1) with conserved zinc finger clusters of 3 to 5 units, while the other class (ZNF91, ZNF74, ZFP37, CTCF) can contain more than 10 zinc finger clusters. CTCF is a ubiquitously expressed, highly conserved transcription factor that contains 10 C2H2- and 1 C2H-type zinc-finger motifs. CTCF binds to and represses transcription at the promoter-proximal regions of c-myc oncogenes,
while CTCF can bind to and activate transcription at the promoter for amyloid β. Another mechanism of CTCF-mediated repression may include binding to insulator regions between enhancers and promoters resulting in enhancer blocking. In addition, CTCF gene may be a candidate tumor suppressor gene, since it localizes to a narrow cancer-associated chromosome region, and has been shown to have tumor-specific rearrangements in breast cancer patients. Thus, CTCF transcriptional regulation may be important for cell cycle progression, differentiation, apoptosis, and tumorigenesis.
Immunofluorescence, Western Blotting
Specifications
| CTCF | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 48 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse, Rat | |
| Human CTCF aa. 184-290 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title