missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PKCα Mouse, Unlabeled, Clone: 3/PKC, BD

PKCα Mouse, Unlabeled, Clone: 3/PKC, BD

Product Code. 15895259
Change view
Click to view available options
Quantity:
150 μg
50 μg
Unit Size:
1 set
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
15895259 50 μg 1 set
15805269 150 μg 1 set
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 15895259 Supplier BD Biosciences Supplier No. 610107

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca2+;, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members ( δ, ε, η, and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι, and λ isoforms) are Ca2+; independent and lack the C2 domain. The aPKC members are unique in that their activity is
independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. Overexpression of PKCα has been reported to lead to an enhanced growth rate and induces the phosphorylation of two cellular proteins of 52kDa and 90kDa.

Host Species: Mouse
Clone: 3
Isotype: IgG2b
Species Reactivity: Rat
Immunogen: Human PKCα aa. 270-427
Formula Weight [Chemical]: 82kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen PKCα
Applications Western Blot
Classification Monoclonal
Clone 3/PKC
Concentration 250μg/mL
Conjugate Unconjugated
Description Protein Kinase C α, PKC-α, PKC-A, PKCA, PRKCA
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human PKCα aa. 270-427
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2b κ
Show More Show Less

For Research Use Only.

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.