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Invitrogen™ ATGL Monoclonal Antibody (615728)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561547
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
Specifications
| ATGL | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q8BJ56 | |
| PNPLA2 | |
| E. coli-derived recombinant mouse PEDF R/PNPLA2, Val162-Gly253. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a |
| Western Blot | |
| 615728 | |
| Unconjugated | |
| PNPLA2 | |
| 0610039C21Rik; 1110001C14Rik; adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; calcium-independent phospholipase A2; Desnutrin; DKFZp667M109; FP17548; IPLA2 zeta; iPLA2zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; plpl; plpl2; Pnpla2; RGD1309044; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; TTS-2.2 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 66853 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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