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Description
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Specifications
Specifications
| Antigen | AVEN |
| Applications | Western Blot |
| Classification | Polyclonal |
| Concentration | 0.38 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | AVEN |
| Gene Accession No. | Q9NQS1 |
| Gene Alias | AVEN, Cell death regulator Aven, PDCD12 |
| Gene Symbols | AVEN |
| Show More |
Product Title
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