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Bcl-2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA511379
Code : LE
Additional Details : Weight : 0.01000kg
Description
This antibody is predicted to react with bovine based on sequence homology.
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.Specifications
Bcl-2 | |
Polyclonal | |
Unconjugated | |
Bcl2 | |
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50 | |
Rabbit | |
Antigen affinity chromatography, Protein A | |
RUO | |
596 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
2.0 mg/mL | |
PBS with 0.09% sodium azide | |
P10415 | |
Bcl2 | |
KLH conjugated synthetic peptide between 75-110 amino acids from human Bcl | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG |