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Invitrogen™ BCL2L15 Polyclonal Antibody
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Product Code. 15654125
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Quantity:
100 μL
Unit Size:
100µL
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15654125 100 μL 100µL
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Product Code. 15654125 Supplier Invitrogen™ Supplier No. PA550194

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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total BCL2L15 protein.

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BCL2L15
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene BCL2L15
Gene Accession No. Q5TBC7
Gene Alias BCL2 like 15; BCL2L15; bcl2-L-15; BCL2-like 15; bcl-2-like protein 15; BCLl2-like 15; Bfk; C1orf178; Gm566; pro-apoptotic Bcl-2 protein; RGD1562344
Gene Symbols BCL2L15
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human BCL2-like 15.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 440603
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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