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  6. Invitrogen™ BRCC3 Recombinant Rabbit Monoclonal Antibody (K01_1N66)

Invitrogen™ BRCC3 Recombinant Rabbit Monoclonal Antibody (K01_1N66)
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Product Code. p-200115101
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30825413 100 μL
30830447 50 μL
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Product Code. 30825413 Supplier Invitrogen™ Supplier No. MA563133

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Description

Rabbit Recombinant Monoclonal Antibody

BRCC3 Recombinant Monoclonal Antibody for Western Blot

Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRCC3
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1N66
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene BRCC3
Gene Accession No. B2RYM5, P46736, P46737
Gene Alias 6.1A protein; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCA1-A complex subunit BRCC36; Brcc3; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36; RP11-143H17.2
Gene Symbols BRCC3
Host Species Rabbit
Immunogen A synthetic peptide of human BRCC36.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 210766, 316794, 79184
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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