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Calreticulin Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 612136

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Product Code. 15836109

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    186.18 € / 1 set
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Description

Description

Proteins undergo numerous modifications, including folding, translocation, and degradation. During such modifications, polypeptides are rarely in a native, stable state. Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through ATP-dependent folding. Many chaperone proteins are found in the endoplasmic reticulum (ER). Calreticulin is a luminal ER protein that is 39% homologous to the ER chaperone protein, calnexin. Calreticulin contains a C-terminal KDEL ER retention signal, and can bind Ca2+;, Zn2+, ATP, and the proteins, ERp57 and protein disulfide isomerase. The molecular chaperone activities of calreticulin may include folding of both Asn-linked glycoproteins and non-glycosylated proteins. In addition, calreticulin is a component of MHC I/transporter associated with Ag presentation (TAP) complex where it may function in peptide assembly onto nascent class I molecules. Calreticulin may also function in integrin signaling, since it binds a3-integrin subunits and regulates integrin-mediated metalloprotease secretion. Thus, calreticulin may be involved in Ca2+; storage, cell adhesion, and protein folding.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Calreticulin
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse Calreticulin aa. 270-390
50 μg
Cell Biology
Human, Mouse, Rat
IgG1
Western Blot
16
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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