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  8. Candesartan, 98%

Candesartan, 98%

Product Code. 15405129
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100 mg
1 g
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Product Code. 15405129 Supplier Thermo Scientific Alfa Aesar Supplier No. J62818.MC
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Description

Angiotensin II receptor antagonist | CAS: 139481-59-7 | C24H20N6O3 | 440.463 g/mol

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in ethyl acetate, methanol, water (<1mg/mL at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 139481-59-7
Molecular Formula C24H20N6O3
Molecular Weight (g/mol) 440.463
MDL Number MFCD00081076
InChI Key HTQMVQVXFRQIKW-UHFFFAOYSA-N
Synonym candesartan, blopress, ratacand, 1-2'-1h-tetrazol-5-yl-1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzo d imidazole-7-carboxylic acid, candesartan ban, 3h candesartan, unii-s8q36md2xx, 2-ethoxy-3-4-2-2h-tetrazol-5-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid, candesartan usan/inn, candesartan usan:inn
PubChem CID 2541
ChEBI CHEBI:3347
IUPAC Name 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O

Specifications

Melting Point 183°C to 185°C
Color White
Quantity 100 mg
Merck Index 14,1739
Solubility Information Soluble in ethyl acetate,methanol,water (<1mg/ml at 25°C),DMSO (88mg/ml at 25°C),and ethanol (1mg/ml at 25°C).
Formula Weight 440.45
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Candesartan

Safety and Handling

compliance-icons
Product Identifier
  • Candesartan
 Signal Word
  • Warning
 Hazard Category
  • Reproductive toxicity Category 2
 Hazard Statement
  • H361d-Suspected of damaging the unborn child.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contain: Candesartan
SDS

RUO – Research Use Only

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