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Invitrogen™ Cardiac Troponin T Monoclonal Antibody (13-11)
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Product Code. 11314753
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Quantity:
200 μL
Unit Size:
500µL
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11314753 200 μL 500µL
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Product Code. 11314753 Supplier Invitrogen™ Supplier No. MA512960

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Description

Mouse Monoclonal Antibody

MA5-12960 targets Troponin T Cardiac Isoform in IF/ICC, IHC (P), and IM applications and shows reactivity with Avian, Canine, Chicken, Fish, Guinea Pig, Human, mouse, Porcine, Rabbit, and Rat samples. The MA5-12960 immunogen is purified rabbit cardiac troponin T isoform (TnT4R).

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
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Specifications

Antigen Cardiac Troponin T
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 13-11
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene TNNT2
Gene Accession No. P02642, P09741, P45379, P50752, P50753
Gene Alias alternatively spliced; cardiac muscle troponin T; cardiac TnT; cardiac troponin 2; cardiac troponin 2 adult #1 isoform; cardiac troponin 2 adult #2 isoform; cardiac troponin 2 embryonic #1 isoform; cardiac troponin 2 embryonic #2 isoform; cardiac troponin 2, exclusion exon 6 #1 isoform; cardiac troponin 2, exclusion exon 6 #2 isoform; cardiac troponin T; cardiac troponin T form I; cardiac troponin T isoform 1; cardiac troponin T isoform 2; cardiac troponin T isoform I; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; MGC3889; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTc; troponin T; Troponin T cardiac; troponin T cardiac isoform; troponin T isoform 1; troponin T isoform 2; troponin T splicing mutant isoform 1; troponin T splicing mutant isoform 2; troponin T type 2 (cardiac); troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T
Gene Symbols TNNT2
Host Species Mouse
Immunogen Purified rabbit cardiac troponin T isoform (TnT4R).
Purification Method Affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009428, 100379561, 100622450, 21956, 24837, 396433, 403532, 7139
Target Species Avian, Canine, Chicken, Fish, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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