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Caspase 4 Precursor (Cleaved Gln81) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5105280
This item is not returnable.
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Description
Antibody detects endogenous levels of fragment of activated Caspase4 resulting from cleavage adjacent to Gln81.
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Specifications
| Caspase 4 Precursor (Cleaved Gln81) | |
| Polyclonal | |
| Unconjugated | |
| CASP4 | |
| apoptotic cysteine protease Mih1/TX; CASP4; CASP-4; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; ICE and Ced-3 homolog 2; ICE(rel)II; ICE(rel)-II; ICEREL-II; ICH2; ICH-2; Mih1; Mih1/TX; protease ICH-2; protease TX; TX | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 837 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P49662 | |
| CASP4 | |
| A synthesized peptide derived from human CASP4(Accession P49662), corresponding to amino acid residues L73-P96. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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