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Invitrogen™ Caspase 6 Recombinant Rabbit Monoclonal Antibody (K01_1K32)
Description
Immunogen sequence: AASVYTLPAG ADFLMCYSVA EGYYSHRETV NGSWYIQDLC EMLGKYGSSL EFTELLTLVN RKVSQRRVDF CKDPSAIGKK QVPCFASMLT KKLHFFPKSN Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 94%, Pig - 98%, Cynomolgus monkey - 100%.
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Spécification
Spécification
| Antigen | Caspase 6 |
| Applications | Western Blot |
| Classification | Recombinant Monoclonal |
| Clone | K01_1K32 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4 |
| Gene | Casp6 |
| Gene Accession No. | O35397, P55212 |
| Gene Alias | apoptotic protease MCH-2; CASP6; CASP-6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; mCASP-6; MCH2 |
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Nom du produit
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