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Invitrogen™ CD223 (LAG-3) Monoclonal Antibody (3DS223H), NovaFluor™ Yellow 700, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen™ H048T02Y06-A
This item is not returnable.
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Description
LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
Specifications
| CD223 (LAG-3) | |
| Monoclonal | |
| 0.4 μg/Test | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P18627 | |
| LAG3 | |
| Affinity chromatography | |
| RUO | |
| 3902 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid | |
| IgG1 κ |
| Flow Cytometry | |
| 3DS223H | |
| NovaFluor Yellow 700 | |
| LAG3 | |
| Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3 | |
| Mouse | |
| 25 Tests | |
| Primary | |
| Human | |
| Antibody | |
| Liquid |
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