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Invitrogen™ AXIN2 Monoclonal Antibody (354214)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561625
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Specifications
| AXIN2 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and no preservative | |
| Q9Y2T1 | |
| AXIN2 | |
| E. coli-derived recombinant human Axin-2, Tyr550-Gln760. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunocytochemistry | |
| 354214 | |
| Unconjugated | |
| AXIN2 | |
| Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 8313 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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