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CD45RB Mouse anti-Human, PE, Clone: MEM-55, Invitrogen™

Product Code. 15215854
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Quantity:
100 Tests
Unit Size:
100 tests
Product Code. Quantity unitSize
15215854 100 Tests 100 tests
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Product Code. 15215854

Brand: Invitrogen A15767

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Description

Mouse Monoclonal Antibody

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45RB
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-55
Conjugate PE
Formulation PBS with 0.2% BSA and 15mM sodium azide
Gene PTPRC
Gene Accession No. P08575
Gene Alias B220, CD45, CD45R, GP180, LCA, LY5, T200
Gene Symbols PTPRC
Host Species Mouse
Immunogen Human CD45RB
Purification Method Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5788
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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