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CD69 Hamster anti-Mouse, FITC, Clone: H1.2F3, BD
Hamster Monoclonal Antibody
Brand: BD Biosciences 557392
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Description
The H1.2F3 monoclonal antibody specifically binds to CD69 (Very Early Activation antigen), an 85 kDa disulfide-linked homodimer of differentially glycosylated subunits. CD69 is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. Its expression is rapidly induced upon activation of lymphocytes (T, B, NK, and NK-T cells), neutrophils, and macrophages. CD69 is expressed also on thymocytes that are undergoing positive selection; its role in that process is unclear. H1.2F3 mAb augments PMA-induced T-cell stimulation and IFN-γ-induced macrophage stimulation. IL-2-activated NK cells express CD69, and H1.2F3 mAb induces redirected lysis of FcR-bearing target cells by NK cells.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
| CD69 | |
| Monoclonal | |
| 0.5mg/mL | |
| VEA; Very Early Activation Antigen; AIM; Activation Induced Molecule | |
| Hamster | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| H1.2F3 | |
| FITC | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse Dendritic Epidermal T Cell Line Y245 | |
| 0.1 mg | |
| Immunology | |
| Mouse | |
| IgG1 λ3 |
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