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CD8a Rat anti-Mouse, APC-Cy7, Clone: 53-6.7, BD

Rat Monoclonal Antibody

255.00 € - 427.00 €

Specifications

Antigen CD8a
Clone 53-6.7
Concentration 0.2mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15821519
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BD Biosciences
561967
25 μg
255.00 €
Each
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Estimated Shipment: 22-04-2024
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10574305
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BD Biosciences
557654
0.1 mg
427.00 €
Each
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Estimated Shipment: 15-04-2024
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Description

Description

The 53-6.7 antibody monoclonal antibody specifically binds to the 38 kDa α and 34 kDa α chains of the CD8 differentiation antigen (Ly-2 or Lyt-2) of all mouse strains tested. The CD8 α and α chains (CD8a) form heterodimers with the CD8 β chain (CD8b, Ly-3, or Lyt-3) on the surface of most thymocytes. A subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells) expresses almost exclusively the CD8 αβ heterodimer (the αα chains arise from alternatively spliced messengers of a single CD8a gene. The longer α form associates with p56 [lck] via a CXCP motif in its cytoplasmic domain, which it shares with CD4, but not with CD8b. The truncated α chain is unable to associate with p56 [lck], and it may function to attenuate the CD8-mediated costimulatory signal during intrathymic T-cell maturation. In vivo and in vitro treatment with 53-6.7 mAb has reportedly been effective at depleting CD8+ peripheral T lymphocytes. The 53-6.7 antibody has also been reported to cross-reaact with CD8 α- and α-like polypeptides on subsets of thymic and peripheral lymphocytes in the Egyptian toad, Bufo regularis.

Specifications

Specifications

CD8a
0.2mg/mL
Monoclonal
Rat
Mouse
Mouse Spleen Cells or Thymocyte Membranes
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
53-6.7
Flow Cytometry
APC-Cyanine7
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
Cd8a; CD8 alpha chain; Ly-2; Lyt2; Lyt-2; Ly-35; Ly-B
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