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CD8a Rat anti-Mouse, PE-Cy5, Clone: 53-6.7, BD
Rat Monoclonal Antibody
127.33 € - 257.87 €
Specifications
| Antigen | CD8a |
|---|---|
| Clone | 53-6.7 |
| Concentration | 0.2mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15810769
|
BD Biosciences
561094 |
25 μg |
 130.00 € 127.33 € / Each Save 2.67 € 2% Off |
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|
15836948
|
BD Biosciences
553034 |
0.1 mg |
268.00 € 257.87 € / Each Save 10.13 € 3% Off |
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Description
The 53-6.7 antibody monoclonal antibody specifically binds to the 38 kDa α and 34 kDa α chains of the CD8 differentiation antigen (Ly-2 or Lyt-2) of all mouse strains tested. The CD8 α and α chains (CD8a) form heterodimers with the CD8 β chain (CD8b, Ly-3, or Lyt-3) on the surface of most thymocytes. A subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells) expresses almost exclusively the CD8 αβ heterodimer (the αα chains arise from alternatively spliced messengers of a single CD8a gene. The longer α form associates with p56 [lck] via a CXCP motif in its cytoplasmic domain, which it shares with CD4, but not with CD8b. The truncated α chain is unable to associate with p56 [lck], and it may function to attenuate the CD8-mediated costimulatory signal during intrathymic T-cell maturation. In vivo and in vitro treatment with 53-6.7 mAb has reportedly been effective at depleting CD8+ peripheral T lymphocytes. The 53-6.7 antibody has also been reported to cross-reaact with CD8 α- and α-like polypeptides on subsets of thymic and peripheral lymphocytes in the Egyptian toad, Bufo regularis.
Specifications
| CD8a | |
| 0.2mg/mL | |
| Monoclonal | |
| Rat | |
| Mouse | |
| IgG2a κ | |
| Affinity Purified | |
| Cd8a; CD8 alpha chain; Ly-2; Lyt2; Lyt-2; Ly-35; Ly-B |
| 53-6.7 | |
| Flow Cytometry | |
| PE-Cyanine5 | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.
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