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Connexin-46 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. 16802065 Shop All Proteintech Products
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150 μL
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150µL
20µL
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16802065 150 μL 150µL
16812065 20 μL 20µL
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Product Code. 16802065 Supplier Proteintech Supplier No. 227171AP150UL

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Description

Rabbit Polyclonal Antibody

Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.

Specifications

Antigen Connexin-46
Applications Western Blot
Classification Polyclonal
Concentration 0.34 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GJA3
Gene Accession No. Q9Y6H8
Gene Alias Connexin-46, CX46, CZP3, GJA3
Gene Symbols GJA3
Host Species Rabbit
Immunogen Connexin-46 Fusion Protein Ag18580
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2700
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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