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CSNK1E Monoclonal Antibody (OTI5H10), TrueMAB™, OriGene

Product Code. 17533053
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17533053 100 μL 100µL
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Product Code. 17533053 Supplier Origene Technologies Supplier No. TA803801

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Description

Mouse Monoclonal Antibody

Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.

Specifications

Antigen CSNK1E
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI5H10
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CSNK1E
Gene Accession No. P49674
Gene Alias CKIepsilon, HCKIE
Gene Symbols CSNK1E
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 153-416 of human CSNK1E produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1454
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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