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Invitrogen™ DUX4 Monoclonal Antibody (P4H2)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA516147

Product Code. 13267568

  • 568.00 € / 100µL

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Description

Description

DUX4 Monoclonal Antibody for Western Blot, IHC (P), IHC (F), ICC/IF

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DUX4
Monoclonal
1 mg/mL
PBS with 0.02% sodium azide
Q9UBX2
Dux4
Synthetic peptide corresponding to the C-terminus of human DUX4.
100 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
P4H2
Unconjugated
Dux4
AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053
Mouse
Protein G
RUO
100288687
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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