Invitrogen™ Endophilin B1/B2 Monoclonal Antibody (807009)

Description

Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.

Endophilin B1 (SH3GLB1) and Endophilin B2 (SH3GLB2) are genes that encode proteins belonging to the endophilin family, which are involved in various cellular processes, particularly those related to membrane dynamics and vesicular trafficking. These proteins are characterized by their SH3 domains, which facilitate interactions with other proteins, and their BAR domains, which bind to and shape cellular membranes. Endophilin B1 and B2 play crucial roles in the regulation of endocytosis, autophagy, and mitochondrial dynamics. They are especially important in the maintenance of mitochondrial integrity and function, as well as in the formation of autophagosomes, which are essential for the degradation and recycling of cellular components. Dysregulation or mutations in these genes can lead to impaired autophagy and mitochondrial dysfunction, contributing to the pathogenesis of various diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's disease, and certain cancers. Research into Endophilin B1 and B2 provides valuable insights into their roles in cellular homeostasis and offers potential therapeutic targets for conditions involving defective membrane trafficking and autophagy. Understanding their mechanisms and interactions is key to developing strategies to modulate their activity for therapeutic benefit.