Invitrogen™ Eotaxin-3-like Polyclonal Antibody

Eotaxin-3-like, also known as CCL26 (C-C motif chemokine ligand 26), is a member of the eotaxin family of chemokines, which play crucial roles in the immune system by mediating the recruitment and activation of eosinophils. Eotaxin-3-like is primarily expressed in epithelial cells and is upregulated in response to inflammatory signals such as interleukin-4 (IL-4) and interleukin-13 (IL-13). This chemokine binds to the CCR3 receptor on eosinophils, promoting their migration to sites of inflammation or allergic reactions. Eotaxin-3-like is particularly important in conditions such as asthma, allergic rhinitis, and atopic dermatitis, where elevated levels contribute to the accumulation of eosinophils and the resulting inflammatory response. It is also implicated in other diseases characterized by eosinophilic infiltration, such as eosinophilic esophagitis. Understanding the regulation and function of eotaxin-3-like is essential for developing targeted therapies aimed at modulating eosinophilic responses and treating allergic and inflammatory diseases. Research into eotaxin-3-like provides valuable insights into the broader mechanisms of chemokine-mediated immune cell trafficking and its potential as a therapeutic target for controlling eosinophil-related pathologies.