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Invitrogen™ EpCAM Recombinant Rabbit Monoclonal Antibody (28), Biotin
Rabbit Recombinant Monoclonal Antibody
189.00 € - 569.00 €
Specifications
| Antigen | EpCAM |
|---|---|
| Clone | 28 |
| Concentration | 1.1 mg/mL |
| Content And Storage | -20°C, Avoid Freeze/Thaw Cycles |
| Applications | ELISA |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30535864
|
Invitrogen™
MA560288 |
100 μg |
569.00 €
100µg |
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|
30533797
|
Invitrogen™
MA560289 |
20 μg |
189.00 €
20µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
EpCAM Recombinant Monoclonal Antibody for ELISA
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.Specifications
| EpCAM | |
| 1.1 mg/mL | |
| ELISA | |
| Biotin | |
| Rabbit | |
| RUO | |
| PBS with no preservative | |
| P16422 | |
| 4072 | |
| Recombinant Human EpCAM protein (Met1-Lys265). | |
| Antibody |
| 28 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human | |
| EPCAM | |
| adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1 | |
| EPCAM | |
| Primary | |
| Protein A |
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