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Fedratinib, MedChemExpress

Product Code. 16443958
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Product Code. 16443958

Brand: Medchem Express HY10409

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Description

MedChemExpress Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.

Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.

Specifications

Chemical Name or Material Fedratinib
CAS 936091-26-8
Color Light Nude
Purity Grade Notes Research
Molecular Formula C27H36N6O3S
Quantity 10 mg
Synonym TG-101348 SAR 302503
Solubility Information DMSO : 125 mg/mL (238.24 mM; Need ultrasonic)
SMILES O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O
Molecular Weight (g/mol) 524.68
Formula Weight 524.68
Percent Purity 98.02%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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