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Invitrogen™ GBA Polyclonal Antibody

Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5120497
Description
Positive test controls include: MCF7, SKOV3, NCI-H460. The target is usually found in the following locations: Lumenal side, Lysosome membrane, Peripheral membrane protein. Immunogen sequence: ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR VPMASCDFSI RTYTYADTPD DFQLHNFSLP EEDTKLKIPL IHRALQLAQR PVSLLASPWT SPTWLKTNGA VNGKGSLKGQ PGDIYHQTWA R.
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Specifications
| GBA | |
| Polyclonal | |
| Unconjugated | |
| GBA | |
| acid beta glucosidase; acid beta-glucosidase; Alglucerase; betaGC; beta-GC; Beta-glucocerebrosidase; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Gba; GBA1; GBAP; GBAP1; GC; GCase; GCB; GLUC; glucocerebrosidase; glucosidase, beta, acid; glucosylceramidase; glucosylceramidase beta; glucosylceramidase beta pseudogene 1; glucosylceramidase-like protein; imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; lysosomal glucocerebrosidase; SGTase | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 2629, 684536 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 1.05 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P04062 | |
| GBA | |
| Recombinant Protein (or fragment). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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