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  6. Halofuginone hydrobromide, MedChemExpress

Halofuginone hydrobromide, MedChemExpress

Product Code. 16483926
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Product Code. 16483926 Supplier Medchem Express Supplier No. HYN1584A

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Description

MedChemExpress Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM.

Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

Specifications

Chemical Name or Material Halofuginone hydrobromide
Physical Form Solid
CAS 64924-67-0
Color White
Quantity 25 mg
Purity Grade Notes Research
Molecular Formula C16H18Br2ClN3O3
For Use With (Application) COVID-19-anti-virus
Synonym RU-19110 hydrobromide
Solubility Information DMSO : 50 mg/mL (100.89 mM; Need ultrasonic) ∣H2O : 2.6 mg/mL (5.25 mM; Need ultrasonic)
SMILES O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br
Molecular Weight (g/mol) 495.59
Formula Weight 495.59
Percent Purity 99.55%
Grade Research
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