Invitrogen™ HMGA1B Polyclonal Antibody

Description

Reconstitute at 0.2 mg/mL in sterile PBS.

HMGA1B (High Mobility Group AT-Hook 1B) is a gene that encodes a member of the high mobility group A (HMGA) family of proteins, which are known for their role in regulating chromatin structure and gene expression. HMGA1B proteins are characterized by their AT-hook motifs, which allow them to bind to the minor groove of AT-rich regions in DNA. This binding can influence the architecture of chromatin, thereby modulating the access of transcription factors and other regulatory proteins to DNA. HMGA1B is implicated in various cellular processes, including differentiation, proliferation, and apoptosis. Overexpression or dysregulation of HMGA1B is often associated with tumorigenesis and has been observed in numerous cancers, such as breast, prostate, and pancreatic cancers. This protein can promote oncogenic transformation by altering the expression of genes involved in cell growth and survival. Additionally, HMGA1B has been linked to metabolic disorders and developmental abnormalities. Understanding the function and regulation of HMGA1B is crucial for developing targeted therapies aimed at modulating its activity in cancer and other diseases. Research into HMGA1B provides valuable insights into its role in chromatin dynamics and gene regulation, highlighting its potential as a therapeutic target and biomarker for disease diagnosis and prognosis.