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Invitrogen™ HTR1B Monoclonal Antibody (499325)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561599
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
Specifications
| HTR1B | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P28222 | |
| HTR1B | |
| NS0 mouse myeloma cell line transfected with human 5HT1B, Met1-Ser390. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin) | |
| 499325 | |
| Unconjugated | |
| HTR1B | |
| 5-HT>1B> receptor; 5ht1b; 5-HT1B; 5-HT-1B; 5HT1B Receptor; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT1DB; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; HTR1B; HTR1D2; HTR1DB; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin 1D beta receptor; Serotonin receptor 1B | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 3351 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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