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ICAM-1 Monoclonal Antibody (1H4), APC, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen A15714
Additional Details : Weight : 0.00280kg
Description
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.Specifications
ICAM-1 | |
Monoclonal | |
APC | |
ICAM1 | |
BB2, P3.58, ICAM-1, cell surface glycoprotein P3.58, intercellular adhesion molecule 1, human rhinovirus receptor, major group rhinovirus receptor | |
Mouse | |
Purified | |
RUO | |
3383 | |
4° C | |
Liquid |
Flow Cytometry | |
1H4 | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
P05362 | |
ICAM1 | |
Human CD54 | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG2b |