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IFIT5 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA566464
Additional Details : Weight : 0.01000kg
Description
Immunogen sequence: THNRPKGKDKL KVDELISSAI FHFKAAMERD SMFAFAYTDL ANMYAEGGQY SNAEDIFRKA LRLENITDDH KHQIHYH Highest antigen sequence identity to the following orthologs - mouse 37%, rat 39%.
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). [UniProt]Specifications
IFIT5 | |
Polyclonal | |
Unconjugated | |
IFIT5 | |
IFIT5; IFIT-5; interferon induced protein with tetratricopeptide repeats 5; interferon-induced 58 kDa protein; Interferon-induced protein with tetratricopeptide repeats 5; ISG58; P58; Retinoic acid- and interferon-inducible 58 kDa protein; retinoic acid- and interferon-inducible protein (58kD); RI58 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
24138 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Western Blot | |
0.4 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q13325 | |
IFIT5 | |
Recombinant Human IFIT5 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
For Research Use Only