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Invitrogen™ ITPRIPL1 Recombinant Human Monoclonal Antibody (6D11)
Human Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA560825
This item is not returnable.
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Description
ITPRIPL1 Recombinant Monoclonal Antibody for ELISA
The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
Specifications
| ITPRIPL1 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
| Q6GPH6 | |
| ITPRIPL1 | |
| Recombinant Human ITPRIPL1 protein. | |
| 100 μL | |
| Primary | |
| Human, Monkey | |
| Antibody | |
| IgG4SP |
| ELISA | |
| 6D11 | |
| Unconjugated | |
| ITPRIPL1 | |
| inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIPL1; KIAA1754L | |
| Human | |
| Affinity chromatography | |
| RUO | |
| 150771 | |
| -20°C or -80°C if preferred | |
| Liquid |
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