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IWP-2, MedChemExpress

Product Code. 16495908
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Product Code. 16495908 Supplier Medchem Express Supplier No. HY13912

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Description

MedChemExpress IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.

Specifications

Chemical Name or Material IWP-2
Physical Form Powder
CAS 686770-61-6
Color Off-White
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C22H18N4O2S3
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMF : 12.5 mg/mL (26.79 mM; ultrasonic and warming and heat to 60°C) ∣DMSO : 2 mg/mL (4.29 mM; Need ultrasonic)
SMILES O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Molecular Weight (g/mol) 466.6
Formula Weight 466.6
Percent Purity 95.68%
Grade Research
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