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  6. KLRG1 Monoclonal Antibody (2F1), Pacific Orange™, eBioscience™, Invitrogen™
  7. 16636474

KLRG1 Monoclonal Antibody (2F1), Pacific Orange™, eBioscience™, Invitrogen™

Syrian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 79-5893-80

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Product Code. 16636474

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Description

Description

This 2F1 MAb reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.

KLRG1 Monoclonal antibody specifically detects KLRG1 in Mouse samples. It is validated for Flow Cytometry
TRUSTED_SUSTAINABILITY
Specifications

Specifications

KLRG1
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O88713
Syrian Hamster
25 μg
Primary
Mouse
Antibody
IgG
Flow Cytometry
2F1
Pacific Orange
Klrg1
2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; KLRG1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Affinity chromatography
RUO
50928
4° C, store in dark, DO NOT FREEZE!
Liquid
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