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Invitrogen™ KSR2 Polyclonal Antibody
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Product Code. 16677664
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Quantity:
100 μL
Unit Size:
100µL
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16677664 100 μL 100µL
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Product Code. 16677664 Supplier Invitrogen™ Supplier No. PA5101188

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total KSR2.

KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KSR2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KSR2
Gene Accession No. Q3UVC0, Q6VAB6
Gene Alias hKSR2; Kinase suppressor of Ras 2; ksr2; RGD1562674; testes-kinase suppressor of ras 2 isoform
Gene Symbols KSR2
Host Species Rabbit
Immunogen A synthesized peptide derived from human KSR2(Accession Q6VAB6), corresponding to amino acid residues K674-L724.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 283455, 333050
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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