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Invitrogen™ LIF Monoclonal Antibody (9808)
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Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA561163

Product Code. 30535206

  • 589.00 € / 500µg

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Description

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LIF
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and no preservative; pH 7.4
P15018
Lif
E. coli-derived recombinant human LIF.
500 μg
Primary
Human
Antibody
IgG1
Flow Cytometry, Western Blot
9808
Unconjugated
Lif
CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Mouse
Protein A/G
RUO
3976
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Lyophilized
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