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PeproTech M-CSF Polyclonal Antibody, PeproTech®, Invitrogen™

Product Code. 17843213
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100 μg
50 μg
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100µg
1mg
50µg
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17843213 50 μg 50µg
17853443 100 μg 100µg
17873103 1 mg 1mg
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Product Code. 17843213 Supplier PeproTech Supplier No. 500P62G50UG

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Description

Goat Polyclonal Antibody

AA Sequence of recombinant protein: MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP. Preparation: Produced from sera of goats immunized with highly pure Recombinant Murine M-CSF. Anti-Murine M-CSF-specific antibody was purified by affinity chromatography employing an immobilized Murine M-CSF matrix. Sandwich ELISA: To detect Murine M-CSF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Murine M-CSF (500-P62GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Murine M-CSF. Western Blot: To detect Murine M-CSF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Murine M-CSF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen M-CSF
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Csf1
Gene Accession No. P07141
Gene Alias C87615; colony stimulating factor 1; colony stimulating factor 1 (macrophage); colony-stimulating factor-1 splice variant; CSF1; CSF-1; Csfm; H-MCSF; lanimostim; macrophage colony stimulating factor 1; macrophage colony stimulating factor alpha; macrophage colony stimulating factor beta; macrophage colony-stimulating factor; macrophage colony-stimulating factor 1; macrophage colony-stimulating factor beta; macrophage-colony stimulating factor alpha; MCSF; MCSF alpha; MCSFBETA; MGC31930; M-MCSF; op; osteopetrosis; Processed macrophage colony-stimulating factor 1
Gene Symbols Csf1
Host Species Goat
Immunogen E.coli-derived Recombinant Murine M-CSF.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12977
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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