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  6. Invitrogen™ MAGEC2 Recombinant Rabbit Monoclonal Antibody (K01_1L17)

Invitrogen™ MAGEC2 Recombinant Rabbit Monoclonal Antibody (K01_1L17)

Product Code. 30830407
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30824625 100 μL
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Product Code. 30830407 Supplier Invitrogen™ Supplier No. MA564665

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Description

Rabbit Recombinant Monoclonal Antibody

MAGEC2 Recombinant Monoclonal Antibody for IHC (P), Western Blot

MAGE-C2/C3 (Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587) is a 373 amino acid protein encoded by the human gene MAGEC2. Genes of the MAGE family direct the expression of tumor antigens that are recognized on human melanomas by autologous cytolytic T lymphocytes. Among tumor tissues, MAGE-C2/C3 is frequently expressed in seminomas, melanomas, and bladder transitional cell carcinomas. It is also expressed in a significant fraction of head and neck carcinomas, breast carcinomas, nonsmall-cell lung carcinomas, and sarcomas. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i. e. the lower the differentiation, the higher percentage of expression. MAGE-C2/C3 is not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. It is strongly expressed in spermatogonia and primary spermatocytes, however, at later stages of maturation, expression gradually decreases to become undetectable in mature spermatids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAGEC2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_1L17
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene MAGEC2
Gene Accession No. Q9UBF1
Gene Alias Cancer/testis antigen 10; CT10; HCA587; hepatocellular cancer antigen 587; hepatocellular carcinoma-associated antigen 587; MAGE family member C2; MAGEC2; MAGE-C2; MAGE-C2 antigen; MAGEE1; MAGE-E1 antigen; melanoma antigen family C, 2; melanoma antigen family C2; melanoma antigen, family E, 1, cancer/testis specific; melanoma-associated antigen C2; uncharacterized protein LOC317590
Gene Symbols MAGEC2
Host Species Rabbit
Immunogen Recombinant protein of human MAGEE1.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51438
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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