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Invitrogen™ MCPT-1 Monoclonal Antibody (285008)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561524
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.
Specifications
| MCPT-1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P11034 | |
| Mcpt1 | |
| Mouse myeloma cell line NS0-derived recombinant mouse Mast Cell Protease-1/Mcpt1, Ile21-Lys246. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 285008 | |
| Unconjugated | |
| Mcpt1 | |
| AV080368; mast cell protease 1; Mcp-1; Mcpt1; mMCP-1 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 17224 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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