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N-Acetyl-D-mannosamine, 98%, Thermo Scientific Chemicals
Shop All Thermo Scientific Chemicals ProductsDescripción
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- N-Acetyl-D-mannosamine (ManNAc) is a precursor used to synthesize N-acetylneuraminic acid, the most common physiologic sialic acid present in humans and other mammals
- Sialic acids are terminal sugars on glycoconjugates that can modify biochemistry of glycoproteins and lipids, mediate cellular adhesion, and act as immune regulators
- Defects in sialic acid biosynthesis are associated with a number of pathologies
- Sialic acids are often found at increased expression levels on tumor cell surfaces
Applications
- As a sialic acid precursor, N-Acetyl-D-mannosamine can be used in many glycoengineering applications, such as modifying immune cell activity, imaging glycans, or blocking pathogen binding
- N-Acetyl-D-mannosamine hasbeen used in preclinical laboratory studies as a treatment for hereditary inclusion body myopathy, a progressive neuromuscular disease via increased sialylation of podocalyxin
- N-Acetyl-D-mannosamine has been used in laboratory studies to induce IgG sialylation and prevent obesity-induced hypertension in mice following high-fat diet
Especificaciones
Especificaciones
| CAS Min % | 97.5 |
| CAS Max % | 100.0 |
| Color | White |
| Infrared Spectrum | Authentic |
| Assay Percent Range | 98% |
| Packaging | Glass bottle |
| Quantity | 5 g |
| Formula Weight | 221.21 |
| Percent Purity | ≥97.5% |
| Physical Form | Crystalline Powder |
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RUO – Research Use Only
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