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Invitrogen™ Nogo-A Recombinant Human Monoclonal Antibody (11D11)
Human Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA560771
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Description
Nogo-A Recombinant Monoclonal Antibody for Flow, ELISA
NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
Specifications
| Nogo-A | |
| Recombinant Monoclonal | |
| 0.44 mg/mL | |
| PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
| Q9NQC3 | |
| Rtn4 | |
| Recombinant Human RTN4 protein. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG4 |
| ELISA, Flow Cytometry | |
| 11D11 | |
| Unconjugated | |
| Rtn4 | |
| 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; Foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; KIAA0886; mKIAA0886; mKIAA4153; My043; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NgA; NI220/250; NI-220/250; NI-250; Nogo; Nogo protein; Nogo-A; Nogo-B; NOGOC; Nogo-C; NSP; NSP-CL; r; rat N; rat NogoA; reticulon 4; reticulon 5; reticulon-4; Reticulon-5; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; RTN-x; SP1507; Vp20 | |
| Human | |
| Affinity chromatography | |
| RUO | |
| 57142 | |
| -20°C or -80°C if preferred | |
| Liquid |
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