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  6. NOTCH1 Monoclonal Antibody (mN1A), eBioscience™, Invitrogen™
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NOTCH1 Monoclonal Antibody (mN1A), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5785-95

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Product Code. 17108495

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Description

Description

The Notch family of transmembrane receptors controls cell-fate decisions during the development of many organs in a wide variety of species. After binding its ligand, the Notch receptor is cleaved in its transmembrane domain, and the resulting intracellular domain dissociates from the membrane and translocates to the nucleus, where it is able to suppress the expression of lineage-specific genes by interacting with transcriptional repressors. The mN1A antibody reacts with the intracellular domain of mouse and human Notch1, but not with Notch2, 3, or 4. The mN1A antibody has a low affinity for the full-length (unprocessed or heterodimeric cell surface) forms of Notch1. In the mouse, Notch mRNA is expressed in mouse hematopoietic cells of the fetal liver and adult thymus and bone marrow. In the thymus, Notch1 protein is detected in CD4-CD8- (double-negative) and CD4-CD8+ (single-positive) thymocytes. Studies of Notch1-transgenic cells and Notch1-null mice indicate that the receptor is involved in the regulation of lymphopoiesis and myelopoiesis.

NOTCH1 Monoclonal antibody specifically detects NOTCH1 in Human, Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry, Western Blot
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NOTCH1
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P46531, Q01705
Mouse
10 mg
Primary
Human, Mouse
Antibody
IgG1 κ
Flow Cytometry, Immunohistochemistry, Western Blot
mN1A
Unconjugated
Notch1
9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; Neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; Notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; NOTCH1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
Affinity chromatography
RUO
18128, 4851
4° C
Liquid
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