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Invitrogen™ Nrf2 Polyclonal Antibody
Description
Recommended positive controls: C8D30, 3xFlag-human NFE2L2-transfected 293T, MDA-MB-231 nuclear extract, MDA-MB-231 nuclear extract (30 μM tBHQ, 4hr), HepG2 (10 μM MG132 treatment for 15 hr). Predicted reactivity: Rhesus Monkey (99%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.
Specifications
Specifications
| Antigen | Nrf2 |
| Applications | ChIP Assay, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.26 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 |
| Gene | NFE2L2 |
| Gene Accession No. | O54968, Q16236, Q60795 |
| Gene Alias | AI194320; E4TF1-60; E4TF1A; HEBP1; Nfe2l2; NF-E2-related factor 2; NFE2-related factor 2; NF-E2-related factor-2; NFT2; NRF2; NRF2A; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2 like 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2; Unknown (protein for IMAGE:7945830) |
| Gene Symbols | NFE2L2 |
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