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NS-2028, MedChemExpress

Product Code. 16487847
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16487847 5 mg 5mg
16465128 10 mg 10mg
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Product Code. 16487847 Supplier Medchem Express Supplier No. HY12379

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Description

MedChemExpress NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity.

NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.

Specifications

Chemical Name or Material NS-2028
CAS 204326-43-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C9H5BrN2O3
Quantity 5 mg
Solubility Information DMSO : 250 mg/mL (929.20 mM; Need ultrasonic)
SMILES O=C1ON=C2COC3=CC=C(Br)C=C3N21
Molecular Weight (g/mol) 269.05
Formula Weight 269.05
Percent Purity 99.0%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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