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Invitrogen™ p27Kip1 Recombinant Rabbit Monoclonal Antibody (HL2508)
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Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556820

Product Code. 30275454

  • 500.00 € / 100µL

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Description

Description

p27Kip1 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

p27Kip1
Recombinant Monoclonal
1 mg/mL
PBS with no preservative
P46414, P46527
Cdkn1b
Recombinant fragment of human p27 Kip1.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
HL2508
Unconjugated
Cdkn1b
AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1
Rabbit
Protein A
RUO
1027, 12576, 83571
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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